Appellation to describe black-wearing art-school-of doom girls. Phrase originated in the early 1990's by comic artist Bill Willingham, who used it to describe the female publishers/artists of a rival comic company (CHAOS Magazine).
Spiderfarmer in common parlance:
Comic Geek: Dude, I'm so going to hit on that spiderfarmer.
Comic Geek2: Don't bother man, she's out of your league. She'll just feed you to her tarantulas.