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1.
to overreact completely, to freak-out, to go mental.
"She heard about what her friend did and went totally spazzcakes."
by yeller9 November 14, 2007
 
2.
Noun. A person who has either had far too much caffeine or is very unusual and/or silly.
"Gia is a spazzcake."
by Belle-Zizi December 29, 2006
 
3.
A state of extreme emotional and intellectual disorientation.
Laura came home from the bar last night, couldn't find her masking tape, and then went totally spazzcakes - she was rolling on the floor in hysterics.
by Lauchlin November 01, 2007