The acronym is used to ask someone the question "Smoke Me Out".

Which means if one is able to let someone smoke marijuana for free.
in text form:

(562) yoo SMO?
(310) i got some extra trees so im down!
by areWHYayeEN July 28, 2010
Get the SMO mug.
When annoyed at someone you say

"you can SMO me".
or "S.M.O me"
by Young Donis April 23, 2009
Get the SMO mug.
short for "someone". Used by lazy typers and fast thinkers.
Yeah, but in the end one would probably end up with smo in his lab.
by Paddy-Whack November 13, 2020
Get the smo mug.