The act of removing a sister from your life, either physically or metaphorically. First used in the Simpsons episode "My Sister, My Sitter".
Simpson? Look, we've already been down there tonight for a sisterectomy, a case of severe butt rot, and a leprechaun fight. How dumb do you think we are?
sistherin is the female version of the term 'bretherin', meaning friend or brother. Thus, as the feminine version, sistherin can be defined as to mean friend or sister.