to tell someone to stop talking. meaning "be quiet" and "stop talking", usually considered to be rude.
dan: that's not what you said.
greg: "shut up dan!"
teacher: we don't use shut up in my classroom.
dan: somebody just did
by themostawesomest November 09, 2008

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another meaning for "no way" or "are u serious?"
"John really really likes you"
"Shut up!"

"Mary is in the hospital."
"Shut up!"
by offlecute5 June 16, 2005

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I Love You
Shut Up,
I Love You Too
by I Love You Becka March 01, 2009

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An awesome song by Blink-182. Seriously it's one of their best songs. "Shut the fuck up she said, I'm going fucking deaf," yes yes, a very good song.
I listened to Shutup for three hours last night
by Maya January 19, 2005

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to tell somebody that they do not know what they are talking about or are just plain irritating
Jord: "I like The Beatles"
James: "I know!!! Shut up Jord!!!"
Tom: " Yeah Jord, shut up!!!" *Tom slaps Jord round the back of the head*
by James Stone December 03, 2006

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Usually considered 'rude' used to tell someone to be quite. Sometimes, shut up is used to express amazement, even if the person it is being directed to is not talking.
"Shut up Meg."

-Peter Griffin

or
"Shut up!"
"I didn't say anything..."
via giphy
by modern wards June 24, 2016

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