Perhaps the most famous line from Cpt. Jean-Luc Picard in the STAR TREK: TNG episode "Datalore". Picard tells Wesley to shut up after he tries to warn the crew that they were actually talking to Lore, Data's evil twin. This also works when someone won't stop whining about something.
OTHER PERSON: You know, I wish you'd listen to me once in a while, because I happen to know...
YOU: Shut up, Wesley!
by OhioMan April 8, 2014
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When you don't particularly enjoy people of African/African American descent, and would like to request that they politely cease being so loud.
Standing in a Walmart checkout aisle, a single man has had enough of the women in front of him's screaming child.

Man: "SHUT UP NIGGER!"
by SlagFromTheEast February 14, 2017
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The best way to win an argument.
Person 1: Did you know that the best way to win an argument is to say "shut up nerd"

Person 2: No it isn't

Person 1: shut up nerd
by TheLionLiar August 29, 2018
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Used to call out someone when they're starting to sound like a crazy conspiracy theorist.
Comes from the classic King Of The Hill show, where Hank Hill would constantly call out his tinfoil hat friend Dale Gribble.
Person 1: "Don't you know the government is listening on everything you say?"

Person 2: "Shut up Dale."
by Anonyfur May 2, 2020
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A response to a question that you don't actually have an answer for.
Person A: If you're not a pedo, why do you have 15 little girls in cages in your basement?

Person B: Because shut up
by MISTER OWNINATOR December 21, 2009
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A quote from the movie Heathers and part of the actual song Big Fun from the musical Heathers. It has nothing to do with TikTok. If you think it's from TikTok or "that one TikTok song" consider yourself educated. Heather Chandler often says it to Heather Duke, and the line is revisited when Veronica yells "SHUT UP HEATHER" at Chandler's spirit. Please refrain from saying "dang dang diggity dang" is from TikTok, it's from Heathers.
Person 1: Shut up Heather!
Person 2: Oh my god, you know Heathers?

Person 1: What do you mean? This is from TikTok.

Person 2: What the fuck? No! It's not from that musical.ly rip-off, it's from an amazing musical!
by ifelloffmychairlaughing November 13, 2019
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If some dude keeps runnin their mouths off and the normal "shut up" won't do the trick, you gots to confuse the shit out of them. When you say "SHUT UP MIGUEL!" you got a 3 second period of silence where you can either run or change the subject.
Some dude: Do you believe in god?

You: SHUT UP MIGUEL

(3 second period to gather yourself)

You: Hey, what did you have for breakfast?

MISSION ACCOMPLISHED
by illegit love child January 25, 2005
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