Top Definition
The most disgusting, most smelly,ugly,stupid,retarded shity peice of crap/thing/creature in the universe is a shishno.

p.s. It is used to describe humans in some alien cultures
A man looks at a bum and says "You fucking Shishno"

or

"hey mikes a shisho, he pussied out of the deal"
by THE GRIMM JOKER February 03, 2008

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