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To annoy or irritate. Usually by wrecking a good thing (i.e. pie) by adding an incongruous irritant (salt).
You know what really salts my pie? I was going to go out this weekend and the professor sprung that essay on us on Friday afternoon.

Man, calm down! Who salted your pie today?

If she doesn't shut up, she's totally gonna salt my pie.
by Mara_the_Obscure December 11, 2005