Top Definition
ruphie is a drug that any age man or women with low self esteem, no morals values uses to take sexual advantage of some one "date rape pill" proper term (rohypnol) is a perscription only sedative.
Bob's friend is a virgin and his bro made him a bet he could not get a girl. So without his friends knowledge he slipped a girl a "ruphie" in her drink. He had sex with her while she was passed out.
by Sunsine Hefner April 12, 2005

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