pertaining not exclusively to being intoxicated, but tired, unhappy, depressed, in-a-rut, anxious, a-regularly-nervous-person, a psychotic, etc....
sober friend: "don't worry about it man, everybody's fucked up! rule 173."
A: "god dam it i'm sooo fucked! i didn't finish the English paper man!"
B: "it's alright, we're all fucked anyway!"