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1.
When someone spikes your drink with a drug without your knowledge.

Effects include vomitting, loss of co-ordination and cognitive abilities, as well as coma induction.
John got roofied the other night!
by snellios April 02, 2006
 
2.
When you get so drunk that someone might as well have spiked your drink.
Yeah man, I don't remember anything...I was roofied!
by spayzant December 19, 2010