Top Definition
To chicken out or back away from something or someone.
As from the movie "Reservoir Dogs":

"Don't pussy out on me now, they believe you, they believe every fucking word you're saying. And you know why? Because you're super cool."
by Freddy February 02, 2004

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To back out of everything like a little girl, especially fights.
Al Ventry likes to pussy out of fights.
by Da Finest!!!! May 06, 2004

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Relating to the word "Pusillanimous", it means to lack courage or resolution. When someone "pussies out" it means they have no backbone, or lack the courage to do something.

Pussy.
"Hey man, you should come chill with us later and take some ecstasy!"
"Sorry, but I don't want to lose an ice cream scoop of my brain cells, thank you very much."
"C'mon man, don't pussy out on me."
by seplion456 February 23, 2010

The Urban Dictionary Mug

Lotsa space for your liquids.

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The Urban Dictionary Mug

Lotsa space for your liquids.

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The Urban Dictionary Mug

Your favorite word on a white mug.

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The Urban Dictionary Mug

One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.

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The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

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The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

Buy the t-shirt