Top Definition
The term came from a forum where gay males posted stroys about having sex with hiv positive partners, linked below. The term basically means to inject hiv positive(poz) sperm into a hiv negitive(neg) anus(hole).

Aw dude you have aids, poz my neg hole plse.
by Bryan Pippers October 01, 2007
6 Words related to poz my neg hole

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