The use of several drugs either in succession or at one time to achieve a certain effect; most drug abusers are polydrug abusers.
I just wasn't getting the high I wanted from the weedso I laced it with coke. Dude,you're a polydrug abuser! Right on!
by Big Momma Stanley September 22, 2010
Polydrug use is the technical term for a cocktail or combination of more than one drug being consumed
by [BATMAN] October 20, 2017