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A 'piss up' is British slang for a drinking session, so if you couldn't organise a piss up in a brewery, you really suck at organising things.
"Im getting married in a few months but I'm going to leave it to Steve to organise the reception"

"Fuck that! Steve couldn't organise a piss up in a brewery... I'll do it"
by L-Shizzle November 15, 2007
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