When someone is piss pilled, it means that they are generally an angry person who is always pissed off, and will likely be miserable their whole lives due to their constant irritability. Dubbed piss pill because of the whole red pill/blue pill whatever pill concept of the matrix, but unlike the other pills, the piss pill makes it's users live a live of "pissful ignorance," or live a life where everything sucks and they're always pissed off.
Person 1: "Bro what's that guy's problem? Why is he such a jerk?"

Person 2: "Ah don't mind Ryan. He's always like that. He's Piss pilled."
by Suckmytoes_77 November 5, 2022
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When someone is referred to as "Piss pilled", it means that they're generally bitter, resentful, and often angry/upset at/towards others for no reason, or an irrational reason. They are called "Piss pilled" as a take on the 1999 film The Matrix, in which there is an option for the protagonist to take the red or blue pill, each with a different consequence. In recent years, red and blue pills have garnered more attention and relevance in popular Internet culture, as they have gained deeper meanings, and more pills have been made up. Too long didn't read, taking the Piss pill means that you have chosen to live a life of "pissful ignorance," or a life where you are always pissed off and everything sucks for you.
Person 1: "Why's that guy such an a-hole? I didn't even do anything and he flipped me off and told me to go f myself!"

Person 2: "Ah don't mind Brian. He's Piss pilled. It's nothing personal he's just a jerk to everyone."
by Suckmytoes_77 November 14, 2022
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