A game, usually in basketball, that starts spontaneously by a group of random people or with friends. There aren't any refs or officiating, and the calls are all on the players, which can get a little unfair and annoying depending on who you play with. The players pick the teams and rules.
*Jack and John shooting around at the court, while Guy 1 and Guy 2 are doing the same on another court*

Jack- Hey, you think we can take those two guys? Let have a 2-on-2 pick-up game with them.

John- I dunno, Guy 1 is 7 feet muscular and black, and Guy 2 is fat, hairy, sweaty, and shirtless. I better not post him up.

Jack- alright then, I call Guy 1, and you'll got Guy 2. We're going up to 21, win by 2, make it take it.
by pseudonym123456789876543 June 28, 2012
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a pick up game, is when you talk to a girl who you have no thoughts of getting with, or if you do but not going out with her. just to keep your game up to stats. cause your picking your game up.
dude i played a pick up game last night on emily.

dude i herd your pick up game with ashely was class a.
by rb26dettgt45 July 17, 2009
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(verb) The act of taking a considerable amount of time in responding to each and every one of your friends birthday greetings on facebook. If you do not start on it early enough on, you face having to spend enormous periods of time in trying to sound appreciative to the masses of people who felt it right to write on your wall for such an annual celebration. It is more regarded as a personal means of thanking the countless persons who wished you a happy birthday; many people dont feel it necessary to take the time to do so and make a thankful status of their approval.
Mom: "So honey, how was your birthday yesterday?"

Son: "Rather uneventful, I spent most of the day writing on other peoples walls thanking them for their birthday wishes. I pretty much played the longest fb pick up game ever.
by crazykidcarlson91 May 30, 2011
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meaning to improve your strategy on winning at the game
person 1: awe I'm terrible at this game
person 2: you better Pick up your game
by adox1922 October 10, 2010
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