A game, usually in basketball, that starts spontaneously by a group of random people or with friends. There aren't any refs or officiating, and the calls are all on the players, which can get a little unfair and annoying depending on who you play with. The players pick the teams and rules.
*Jack and John shooting around at the court, while Guy 1 and Guy 2 are doing the same on another court*
Jack- Hey, you think we can take those two guys? Let have a 2-on-2 pick-up game with them.
John- I dunno, Guy 1 is 7 feet muscular and black, and Guy 2 is fat, hairy, sweaty, and shirtless. I better not post him up.
Jack- alright then, I call Guy 1, and you'll got Guy 2. We're going up to 21, win by 2, make it take it
a pick up game, is when you talk to a girl who you have no thoughts of getting with, or if you do but not going out with her. just to keep your game up to stats. cause your picking your game up.
dude i played a pick up game last night on emily.
dude i herd your pick up game with ashely was class a.