Top Definition
Phosphorylation is the addition of a phosphate (PO4) group to a protein or other organic molecule. The addition of phosphate groups in proteins changes the way they wiggle and so changes what a protein does.
In a cellular signaling pathways, a protein A phosphorylates protein B, and B phosphorylates C.

I will phosphorylate you so hard your great grandmothers cells will undergo apotosis... again.
by superkuh_ July 10, 2009
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