A particularly bad dose of permalag - persistent jet lag where the traveler shuts down all non-vital functions in order to survive the rest of the journey. Kicks in after ~60 days of back-to-back time zone crossing travel and high-stress meetings. Signs of permaphuck include: exhaustion; extreme anti-social behaviour; and waking up not knowing what continent you are in.
Travelers have been known to survive for weeks in a state of permaphuckedness - by switching to auto-pilot and falling back on learned behaviours. There are however long term side effects: deteriorating health; a trail of broken relationships; an unhealthy awareness of and desire to talk about airport lounges.
Some travelers believe that permaphuckedness is a result of their soul trying to catch up with their physical self.
The use of "phuck" stems both from its use inside corporations where employees are trying to side step the email monitoring algorithms, and on blogs etc where the writer is trying to avoid being listed as a porn site.
I'm so permaphucked I could crawl into a ball and die.
The only way I'm going to ride out this permaphuck is to keep drinking.