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6.
which the user of the drug (mainly LSD) feels some effects of the drug (example; sever memory loss) for a vary long time after use of the drug year possibly longer ( the conduction will get better over time but user may never feel quite the same)
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1.
Being stoned so often that your mental state is permanently altered.
The Red Hot Chili Peppers are probably permafried by now.
by Salieri_82 May 27, 2006
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2.
Permanently-Fried. When you do so much acid you never come down completely and are never the same. Does NOT mean flash-backs, that's different.
He did way too much acid a few years ago and he's been permafried ever since.
by rubicante June 13, 2003
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3.
to be permanently effected by drugs, even after not taking them for a while.
i don't think weed or acid permafry people, but cocaine will change someone for life.
by minghi May 21, 2003
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4.
v 1. to appear as if on drugs, even though one is sober.
"Wow that Mark Fry kid is perma-fried."
by MF September 05, 2002
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5.
To have taken so many drugs your brain is irreversably fried
John Saunders went way too hard for way too long but hasnt touched drugs in 10 years. Even after such a long period of sobriety he shows signs of serious brain damage and as such is permafried
by rocketdogz September 20, 2010
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7.
To have done so many drugs, that one would expect you to be affected by drugs 24/7, even though you might not be, but you probably are.
James: Alex are you high?
Alex: Dude i dont even know i have done it like four times today already.
James: you must be perma-fried
by Free Weezy June 07, 2010
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