1. When a person overreacts to a trifling insult or barb, or to a joke.

2. When someone acts in an anal-retentive manner, and makes a big fuss out of a relatively minor problem.
1. Don't get you're panties all in a bunch, he doesn't mean it.

2. It's not that big of a problem, don't get your panties all in a bunch, it's going to be okay.
by teh pope January 18, 2005
when a party or subject begins to act in an anally retensive manner; stupid hoe bags that try to front when they styles ain't fly.
Damn bitch, why you gotta be gettin' your panties in a bunch?
by swimsuit May 09, 2003

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