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It's a word that's used with Italians or Italian Americans when informally, but friendly, adressing one another. It means "brother" or "fellow countryman". Shortened from paisano, and is sometimes spelled paesan.
"Hey, paisan! How's the veal parmigiana?"
"Delicious, best in the city!"
paisan by Alumita November 11, 2005
Related Words
n. means countryman or brother in Italian. The equivilent of "homie" to Italians and Italian-Americans.
Usually spelled paesano.
Sometimes shortened to paesan or paisan
Yo, howyoudoing, paisano?
paisano by Jam Master J April 14, 2005

Paisano/Paisan

Paisano/Paesano/Paisan -Italian(n) referring to another Italian(n)who is from the same village or area/region in Italy.
Countryman
Alfredo is a Paisano/Paisan also from (name of ancestral homeland-village) or region of Italy; as in Marchegiano (a person from the region of Le Marche).

Passanisi 

Crazy drunks from up the river
"who is that guy wearing a pink too-too dancing on the bar?"

"He must be a Passanisi"
Passanisi by jpass June 6, 2009
Italian, usually said in reference to 'buddy, friend, mate'. Also in the diaspora used to describe Italians from same village your ancestors came from.
"You know Domenico, don't you? He's a paisano (from the same village)"

"Hey paisano"
paisano by MatteoP December 9, 2008
A word used by italians toward other italians meaning "Italian brother" sometimes shortened to Paisan.
"Capisci Paisano, Si o no"
"Ay paisan, how ya doin"
paisano by tony two toes February 16, 2005