Top Definition
1. Adj. 'Totally obliterated'

2. Transitive Verb. to go Osama, turn against your friends. Declare a holy war on a person, thing, or place.
1.) Your friends house was totally osamaed after the party.

2.) The man went osama at the post office luncheon, and started punching everyone.
by MB March 30, 2004

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