Top Definition
OR-ee-oh-BOT-to-mee: the surgically precise removal of an oreo cream centre. Originates from the 2005 children's novel Barry, Boyhound.

There are numerous techniques to performing an oreobotomy, such as incisordectomy and twistology. It is quite difficult to execute the procedure perfectly.
Wow, look at that! Dan just performed a perfect oreobotomy!
by turntechShithead June 22, 2012

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