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1.
Weed that will get the smoker high in one hit. Usually very expensive, but worth it.
Come to the party, we gonna get some one hit quit shit.
by Unho1y Gost April 24, 2005
 
2.
A one-hit-quit is when something is so good that you don't need a second opinion or backup to know it. You found it.
When I met Nick, I knew he was a one-hit-quit, I didn't need or want anyone after him... he was *that* good. I got everything I needed and nothing else could compare.
by coolest laura in wyoming January 15, 2011