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1.
Abbreviation for "Oh My God, You Suck."
You were the one who stole my wallet? OMGUS!
by Ian Maxwell November 03, 2002
 
2.
Phrase to direct at an annoying person such as Andrew, meaning 'oh my god you suck!'
"omg girls aloud are so hot"
"OMGUS!!"
by Spoonicorn January 28, 2006