Many people think of Ohio as a state full of cows and hicks; while this is true, it's also true that the major cities have serious problems with gangs, crime and violence.
Many other contributors have mentioned that Ohio smells funny. This is because a large portion of the population hardly ever showers or changes their clothes.
Most people in Ohio are unfriendly and unintelligent. Also the weather sucks and is insanely unpredictable.
Ohio also boasts the worst drivers in the entire nation; they do not seem to understand the meaning of a green light (they believe that a green light means they should slow down and/or stop their car.)
Ohio is mostly a flat and boring state. The only really good thing about Ohio is Cedar Point, the number one rated amusement park in the US. Also, Ohio has one of the largest state fairs in the nation and Columbus has one of the largest fireworks displays in the nation. Oh, plus there's a GameWorks. Other than that, there's not much to do in Ohio, especially during the winter months.
Ohio is a nice place to visit during the summer if you want to see some of the attractions, but you definitely don't want to have to live there.