oftwenty Share definition Flag A play on the word often, in that instead of 'ten' in the name, there is 'twenty'. A more forceful usage of often. Gamer 1: "Dude, my game froze! I lost so much progress!"Gamer 2: "You gotta save oftwenty, man." oftwenty by Jze March 30, 2010 0 0 Get merch Get the oftwenty mug. Buy Now — $32.95 See more merch