The new "that's what she said". When some derragatory remark is said, another person remarks "my wife or my sister?". Another person is to respond "what's the difference?"
"Let's go to that all-you-can-eat-buffet!"
"My wife or my sister?"
"What's the difference?"
by sexxxxxxxxxx December 13, 2008
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When you do or say something that makes you seem retarded. From the Hallmark Hall of Fame movie of the same name starring Rosie O'Donnell in which she plays a "challenged" person who, surprisingly, rides the bus with her sister. What could have been a touching portrayal was ruined by the fact that she spent the majority of the movie screaming and acting like an insane monkey rather than a noble portrayal of a person with mental handicaps. So really, you are acting more like an insane monkey than a retarded person. Can be shortened to Riding the Bus.
"Do you really think you should wear leggings under your skirt? It's a little Riding the Bus with My Sister."

or

"Don't talk so loud in the movie theater. It makes you too Riding the Bus With My Sister."
by The Carester September 13, 2005
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someone in my family that pisses on anything but i still love her
ignore the bottom line

my baby sister
me: leaves clothes on the floor.
her: pisses on them

ignore this
my baby sister
by minecraftgoatttt August 31, 2021
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Commonly used as an excuse to get out of something you can't do and or when you previously had accepted a invitation to something but need to get out of it. Having a sister may or may not be true and she may or may not live in Freo. This is irrelevant as the emphasis is having a plausible excuse, not on actual fact.

Can be embellished with descriptive addiction as such as ...for a family do or to go watch a football match.

Feminine form of i need to take my little brother to baseball practice
"Damn, sorry to do this, but it can't make it this afternoon, I have to see my sister in Freo"
by Ttaym October 17, 2013
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someone who annoys you, loves you and is always there even when you don't particularly need her
she spilled orange juice over my new shirt, yea that's my little sister.
by dr. gerbil January 5, 2017
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My enemy.
- My brother/sister is as lank as a twig.
by Spacet September 3, 2022
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An annoying 8 y/o who will do anything to get on your nerves.
“My little sister is such a pain in the ass
by ThatBitchAT May 18, 2021
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