Top Definition
Staph Infection (Staphylococcus aureus) of the vagina area.
May cause rashes, boils, and stinky pussy.
Justin: Hey you know that girl that plays on the softball team?

Dave: Which one?

Justin: You know the one with the muffstaph.

Dave: Oh ya that shit is Fucking sick.
by dumnumyuk July 28, 2009
5 Words related to muffstaph

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