Top Definition
when you are itchy all over and not sure of the cause: when anything irritates your skin such as fabrics, pets, soaps and you keep scratching yourself and can't stop
This all started when I used a cheap generic fabric softener in the dryer. I forgot the name of it, but the word "fluffy" was in the name. Everyone in the household started itching and scratching the next few days. So now when anyone is scratching for any reason, they say " I think I have a case of Mr. McFluffy disease!!!!"
by mougie December 16, 2013

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