Top Definition
(v): To use some object (notecard, toothpick, paperclip) to clean that weird, greasy gunk that builds up in the little cracks of your computer mouse.
I haven't mouse-flossed in months, and then I looked and saw all sorts of nast. * folds up a piece of paper and starts mouse-flossing *
by Mystakaphoros October 09, 2013

Free Daily Email

Type your email address below to get our free Urban Word of the Day every morning!

Emails are sent from We'll never spam you.