Top Definition
(v): To use some object (notecard, toothpick, paperclip) to clean that weird, greasy gunk that builds up in the little cracks of your computer mouse.
I haven't mouse-flossed in months, and then I looked and saw all sorts of nast. * folds up a piece of paper and starts mouse-flossing *
by Mystakaphoros October 09, 2013

Free Daily Email

Type your email address below to get our free Urban Word of the Day every morning!

Emails are sent from daily@urbandictionary.com. We'll never spam you.

×