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1.
1) Usually spoken with a drawn out emphasis on the last syllable; mofoshee is used to replace a combination of "mother f***er sh!t" when one needs to express themselves quickly.

2) A response to something that is though as being unbelievable, or a mistake
1) A dogg, let me holla at cha' mayne', we gon' go do dat mofoshee right now yo'

2) Person A: Dogg, I just bumped dirtys with your girl.

Person B: Mofosheeeeeeeeee, you ain't do nothin'
by MattsSi February 03, 2004