A friendly or joking way to refer to someone as a mother fucker. "Mofoesy" removes any element of anger associated with the word "mofo". This term can only be taken by the receiver in a light-hearted manner. Whereas one might nickname a friend named "Jones" as "Jonesy" the same kind of affability applies when substituting mofoesy for mofo.
"yo mofoesy, what you up to?"
by Dan Moses June 05, 2007