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1.
Yiddish for "craziness".
"Ok, you should have seeen the mishigas ... the whole family was there, all the cousins were runng around, babies crying, etc."
by sfasdfasdf September 29, 2005
 
2.
Stupidity, craziness, irresponsible behavior.
"Moishe, you should not be putting dirt in your pants. End this mishigas immediately."
by AnonAnontheAnon August 22, 2011