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1.
A play on words (created by one Jon Stewart) which serves on The Daily Show as a reoccuring update on the War in Iraq. The term originates from the word mesopotamia, an ancient region of Iraq. The area was the home of numerous early civilizations and declined in importance after Mongol invaders destroyed its extensive irrigation system.

Other variation: mess-o-potamia, mess o'potamia
Here is the latest report..on messopotamia.
by Athena Kay September 28, 2004
 
2.
john stewarts defination of the war in iraq... HE IS RIGHT EVEYONE, DOWN WITH BUSH DOWN WITH WAR!!
"and now we turn to the events in that great big land called messopotamia"-john stewart