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Newfoundland slang for being annoyed, pestered, irritated. Another way of saying "that gets on my nerves". Another way of saying "my patience is gone". It is also sometimes used as a response - instead of oh my gosh, no way, get outta here.
Mary: How are you today Donna?
Donna: The youngesters are driving me crazy!
Mary: Why, are they being annoying?
Donna: Yes, me nerves is rubbed right raw!
Mary: oh me nerves oh me nerves is gone
by The Gewfie Newfie January 19, 2011