man to man, one on one, usually used in the context of a physical confrontation / altercation between two gentlemen.
okay, buddy, you and me, mano e mano.
by themarcuscreature February 21, 2005
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"mano y mano" is Spanish for Hand to hand. Usually associated in engaging in throwing fisticuffs with two or more people, usually two.

Is layman's terms, a fight, but not usually followed closely to it's meaning. Often times, swords, or other weapons, not involved with guns or firearms, are associated with the term.
All right, Robin. Let's go at it. a fight to the death, you and me, Mano y mano, just you and me and my GUARDS!
by Kincaid Kjeedo June 10, 2006
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when you go full warfare one on one man on man (don't think about) battle to the death
dude 1: minecraft is trash
dude 2: nah fam
the creepy world narrator: there going mano 'o' mano
by the-great-jet December 3, 2021
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