A combination of "mah" (my) and "nigga", with the catch-all "izzle" ghetto suffix.
"Wassup, manizzle? I shonuff ain't seen you fo longass time."
by Altratronic October 19, 2007
2 more definitions
As in the AOL commerial when Snoop Dog said, "Now wait just a manizzle!"
by Connah December 05, 2003
From the Backround of Nigro folk, It was founded on the basis of use in Rap, and Gangsters chizzlin' in the hizzle fo shizzle.
Now wait justa manizzle!
by A Cracka February 15, 2005