To insert one's hand into the anus of male sexual partner. Typically used to describe homosexual activities.
After pounding Ernie for well over an hour, Bert dismounted and proceeded to give him a Manhattan Handshake before jizzing on Ernie's face.
by ManhattanHandshaker April 26, 2013
A sharp knock to one's testicles by another individual in a group of buddies drinking in a crowded bar. Usually this is unwarranted, unwanted but very funny to everyone except the one who was just knocked.
As Dave ordered another round at the bar, he was surprised by the Manhattan Beach Handshake and folded like a house of cards.
by Can't kill a man born to hang! August 12, 2008