It is a condition where a small or short man will be generally more agressive towards tall or larger men.

The person with Little Man's Disease is trying to make himself seem stronger or better than the bigger person and is generally hostile or moody towards them.
'That geezer over there must have little man's disease. Look at him trying to start a fight with them to massive guys'.
by Oliver Vantini August 5, 2008
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Little Man’s Disease: A disease of short males marked by aggressive antisocial behavior and constant overcompensation resulting in pompous mannerisms such as spitting, twitching, swearing, speaking loudly and tough talk.
The disease only affects teenagers or men who are less than 5’ 6” tall. The severity of this disease is inversely proportional to the height of the sufferer. Other characteristics of this scourge are a very short penis, acne, low I.Q and bad etiquette. The poor bastards usually drive jacked up pick-up trucks lacking mufflers. Often these males are homophobic to the point of insanity because of latent sexual orientation issues.
You must have Little Man’s Disease.
He is such a worthless asshole he must have Little Man's Disease.
Little Man's Disease is an untreatable epidemic in this country.
Some of my best friends have Little Man’s Disease.
by Dr. Vinnie Boombaa April 25, 2007
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When a male is generously short. This particular male feels the need to have a big bark. They feel emasculated when their bark is big!!! It covers up their extremely little legs. When everyone knows the bark is bigger than the bite.
Matt walks around all day looking up at people! He is very jealous that he’s not tall like all the other boys, so he shouts profanities at them !! he' is only 5'4:( he has little man syndrome!
by Amy Jae August 12, 2019
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A midget that acts like a dic and tries to be tough because he’s an insecure little fuck
Ok Michael, why u so salty ? U got little man syndrome ?
by Saavyjavi January 12, 2022
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When a guy is short and has an attitude problem because he is bitter at society for looking down on short guys.
Damn, I just got rejected by the bouncer that I was a lot taller than at the bar, he must have had a bad case or little man syndrome.
by Erica April 24, 2004
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A person who thinks that he/she is bigger than they really are and tries to fight anyone as a result of it.
by Ian Cash December 26, 2011
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