To a very large extent; a lot.
The Big Unit: "So Mike, how'd it go with that bitch last night? Did you pull the freund on her?"
Mike Piazza: "Hell yeah dogg, like it ain't no thing."

Bob: "What up Joe."
Joe: "Nothing playa, just hangin' out, being broke, doing nothing."
Bob: "Whatever man, you're family is fucking loaded. And you're always freaking out that you have too much shit to do."
Joe: "W-W-Whatever man, that's bullshit. I'm just keepin' it real, ya know what I'm sayin'. And I really have no money. I've got nothing like it ain't no..."
Bob: "Shut up. Bitch."
by Nick D November 5, 2003
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1) Something that was done easily
2) When someone pretends something was done easily.
1) "I date 3 guys at once like it ain't no thang"
2) "George Bush is going to win this war like it ain't no thang"
by Kristen December 3, 2003
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almost to an end, to a large extent
Matt: Yo dave look out there, look at that hot ass biatch shakin it like it ain't no thing
Jack: holy shit dave that looks just like your mom!
Dave: man, not again
by Matt H December 17, 2003
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