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Wouldn't know what to do with a pussy if he had one. 

What is said of a guy that knows almost nothing about sex. For example nerds,noobs,strightedges/strightasses,bible thumpers,mama's boys ect.
That nerd wouldn't know what to do with a pussy if he had one.

I don’t know what to do

UD Jews, I’m talking to you guys

I’m very confused and am unsure as to what I should do.

My friend said I know the truth and that I shouldn’t be worrying. But things are getting really tough.

Will the stock market crash soon or will WW3 break out soon? That would kinda give me an advantage.

Do you know what to do with a box of bees? 

This question tests if an adult male is a real man or not. A woman asks when assessing if an adult male is worth being in a romantic relationship with. If the guy says yes, he is a real man. If he is confused by the question, he is not worthy. If he says no but expresses interests in improving himself, don't write him off as a not-man yet. there is still hope
"Mike, do you know what to do with a box of bees? "

"uh, no?"

"then learn or go away. I only date REAL MEN."

I don't know what I'm going to do with you! 

Significant other is fed up or exhausted with the idea of you being around them.
Justin, you are getting to be too much and I'm confused about how I should handle you! You have made me mad/annoyed for the last time!!
("I don't know what I'm going to do with you!" is to be aggravated or annoyed by one's actions)

<.7.9.7.6.>We Do not Know What Happened To Nairobi Valenzuela After Angel JosE robles Left The room in apartment 2G<.7.9.7.6.> 

<.7.9.7.6.>We Do not Know What Happened To Nairobi Valenzuela After Angel JosE robles Left The room in apartment 2G<.7.9.7.6.>
<.7.9.7.6.>We Do not Know What Happened To Nairobi Valenzuela After Angel JosE robles Left The room in apartment 2G<.7.9.7.6.>

<.7.9.7.6.>I Do Not Know What I Did To Deserve This But I will Kill YOu <.7.9.7.6.> 

<.7.9.7.6.>I Do Not Know What I Did To Deserve This But I will Kill YOu <.7.9.7.6.>
<.7.9.7.6.>I Do Not Know What I Did To Deserve This But I will Kill YOu <.7.9.7.6.>