Top definition
1. A gesture of confirmation.
2. Another way of saying "okay".
3. In good condition.
Used by Mr. Saturn in the SNES game Earthbound.

Can you get me that book over there?
"Kay-O".

"Are you kay-o?"
by David S May 17, 2006
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2
Rikishi kayoed Mysterio with his ass!
by bambooed December 09, 2009
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3
Someone who calls a woman "whore" or "slut" because he knows she is out of his league and that she would mock him for the size of his penis.
That poor dude is such a kayos he couldn't get water from the town pump.
by Citizen Kayos March 06, 2008
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4
Hiding cocaine in Mayonaisye Jars and being okay with it.
Thug 1: Did you just hide your Yayo in your Mayo?
Thug 2: yeah it's called Kayo
by Dus10_L January 02, 2015
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5
He is very believing and he has a dick that he fucks his dog Max
"KAYO STOP FUCKING MAX! HES DYING OF BARKING"
by KKKGOD April 02, 2017
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