messing, joking, or fucking aroung with someone or something.
Amanda loves to jack with me.
by Amy August 10, 2004
To fuck with. What someone does to mess with someones stuff or property.
Who has been jackin' with my schlitz?
by todman August 09, 2004
To "jack with" someone is to tell someone a lie in a way that will make that person believe you. To mess with someone, to pull a person's leg.
The used car salesman jacked with the ignorant teenager.
by SRS August 09, 2004
to mess with someone or something
Some drugs can really jack with your brain.
by The Return of Light Joker March 15, 2011