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The drowsy sleepy feeling you get after eating a large meal. Usual meals like big Sunday dinners, Thanksgiving and Christmas meals.
Man that itis done got me. I'm fixin' to take a nap.
by Malinen23 December 12, 2005
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2
A variation and shortening of Niggaitis; The overwhelming sleepy feeling that comes over people after they have eaten too much food. Usually people get the 'itis after eating rich soul food during the holidays.
I have the itis so I am going to lay down and take a nap.

I don't want to eat too much because I will get the 'itis.
by Berry August 16, 2004
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3
The feeling you get after you eat tons of food. You feel drowsy and do not want to do anything all day.
John:"yo bro, all of that Mexican food at Burrito Bandito gave me the itis."
Sam: "I know dude, I just wanna lay down and sleep dawg."
by Kolvk October 03, 2012
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4
verb. i-tiss

Drowsy or sleepy effect linked to digesting large meals, usually high in fat or salt content.

Note: The digestive system uses roughly 60% of your energy while you idle about daily, so after eating large meals the digestive system takes energy from other areas of the body, allowing it to work faster, and bringing about a sleepy effect.
Melinda planned on waking up early and doing some shopping on Black Friday, but after her huge Thanksgiving meal the itis set in, and she woke up late in the afternoon.
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5
a naturally occuring drowsy feeling that is created when a person, normally of the African-American race (although it may affect peoples of all creeds), eats a large amount of fried, salty, or fatty foods...this feeling usually causes one to sip some purple drank and take a nap
i dun ate all the KFC, the itis got me....wake me up when Cosby's on
by J O R D A N July 25, 2006
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6
The itis is the short name for the colloquial ebonics tern "niggaitis" meaning the feeling of overwhelming sleepiness that hits black people mostly following eating. Of course the "itis" is not restricted to black people and is also known by its medical name "alkaline tide"
"the itis hit me so hard after that fried chicken and waffles I feel like I'm gonna pass out"
by kidsruledoc July 06, 2012
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7
The feeling which one experiences after eating a large meal. Usually characterized by sluggish, drowsy, tired, or lethargic feelings.
Mark: "Wow, you just ate like three Big-Macs"
Andrew: "Yeah, the itis has really started setting in"
by Mark TB January 31, 2009
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