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1.
A term penned by the east bay funk group Tower of Power.

A condition that describes someone who lacks rhythm, is a bad dancer, or someone who is an all around stiff white boy.
The solution to this widespread problem is soul vaccination
That boy's got the honky pox
by Radix October 13, 2005
 
2.
Sexually transmitted diseases caught from someone met in a honky tonk. Although not confirmed to exist, the possibility of running into honky pox in the honky tonks is plausible.
We got ritonkulously drunk at the Second Fiddle last night and Jack ended up humping a girl in my bed. I hope she didn't have honky pox.
by broadwaytonker April 18, 2009