Close buddies, especially in the case of white guys. Derived from fractured slang terms homiesor homeboys.
From SNL Season 25: Episode 13: "And just because we are homesnakes, I throw in free, complimentary windshield wiper fluid."
by PGizzle March 03, 2007
A term used for a scruffy stray cat at my work.
Hey, there goes Home Snake
by Clay August 23, 2003