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Close buddies, especially in the case of white guys. Derived from fractured slang terms homiesor homeboys.
From SNL Season 25: Episode 13: "And just because we are homesnakes, I throw in free, complimentary windshield wiper fluid."
by PGizzle March 03, 2007
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2
A term used for a scruffy stray cat at my work.
Hey, there goes Home Snake
by Clay August 23, 2003
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