Top Definition
A female that is getting on your last nerve. One of them hoes that don't know their place or when to shut the fuck up. It could be a nasty hoe as well.
I just can't stand a slick, co-signing heffa hoe!
That heffa hoe still talking shit?!
by CFBossBish January 13, 2015
a term of enderment orginaly founded on myspace by josh and aj. means a close freind can also be used offensively if pronounced heffer-hoe
good way:I`m chilling with my heffa-hoes
ba way: That girl is a fat Heffer-hoe
by heffa-hoe July 22, 2006
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