Irritating question best used after arguing with someone, and then proving them wrong. Once they realise that they are being beaten, or are wrong, say in a high, stoned voice: "Haaaave you no friends?!?"
<SergioTehArab> HAHAH THOSE FUKING ASAIN PPLZ THORT IT WULD B FUNNAY TO KNOK DOWN THE EMPYRE STAET BILDING!1
<NeeSheeShee> That never happened, assface.
<SergioTehArab> ...
<NeeSheeShee> HAAAVE YOU NO FRIENDS?!
It is said of the situation where a person has the bad luck to make contact with his testicles against an undefined surface or object, intentioned or not.
Given the nature of the word, it is more appropriate to design cases where the interaction is made with a moving object, for example, a ball.
Although it is extremely painful for the victim, it tends to be considerably funny to people who witness it.
Today in the baseball game the pitcher took a nutshot; the baseball hit him in the nuts.
Man, I just watched the funniest nutshot video ever.